Don't bother with super skill shot (soft plunging and hitting Venom with upper flipper). The 2x bonus from the regular skill shot is better.
Doc Ock multiball is a good time to hit the dangerous "Light Lock" target to light the locks for Black Suit multiball
Complete white spiders and shoot either outer loop to start one of four modes.
After successfully completing a mode the next major shot you make will be tripled for the rest of the ball.